Hydroxytyrosol and Covid-19: what we know

A very recent interesting publication (“Proposal of a food supplement for the management of post-COVID sindrome” Z Naureen et al. Eur Rev Med Pharmacol Sci; 2021) included hydroxytyrosol into a combination that demonstrated to improve the perceived fatigue on post-Cobid-19 patients with chronic fatique.

It also included L-Carnitine, hydroxytyrosol from olive, vitamins C, D , B1, B6, B2 and B9 improved perceived fatigue on post-COVID patients diagnosed with chronic fatigue.

As you know, majority of COVID-19 patients experience fatigue, extreme tiredness and symptoms that persist beyond the active phase of the disease, Long/Post Covid. The mechanisms by which the virus causes prolonged illness are still unclear.

They filled in an Activation-Deactivation Adjective Check List self-assessment questionnaire at the beginning and end of the study period. It is a multidimensional test of various transient arousal states, including energy and nervous arousal.

After taking the supplement for 15 days, supplement users recorded more improvement in energy and psychological status than non-users. Self-reported energy levels doubled after 15 days on the food supplement (+123%), whereas levels of tiredness and tension halved, -51% and -48% respectively. The non-user group reported an increase in energy and calmness and a decrease in tiredness and tension but both were much less than those recorded by the user group.

Hydroxytyrosol is a powerful antioxidant phenol compound. It also has anti-inflammatory properties.

Post-COVID fatigue and tiredness may be linked to continuing inflammation, mitochondrial dysfunction, accumulation of damaged mitochondria and protracted infection due to prevention of cytotoxic killing of infected cells.

“Food supplements having antioxidant and antiinflammatory activities, not only help the body fend off viral infection but also boost immunity and prevent prolonged postCOVID fatigue and gastrointestinal problems. In this way, they promote overall health and improve the quality of life of patients who have managed to recover from SARS-CoV-2 infection” (Mrityunjaya M et al., “Immune-boosting, antioxidant and anti-inflammatory food supplements targeting pathogenesis of COVID-19”; Front Immunol 2020)

Another sstudy showed that a treatment with α-cyclodextrin and hydroxytyrosol nasal spray improved defenses against SARS-CoV-2 infection and reduced synthesis of viral particles (“In vitro and clinical studies on the efficacy of α-cyclodextrin and hydroxytyrosol against SARS-CoV-2 infection; S Paolacci et al.; 2021 Eur Rev Med Pharmacol Sci).

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