A recent publication (Shenlin Liu et al; J Agric Food Chem 2024), evaluated the protective effects of HT on obesity-induced cognitive impairment.
A high-fat and high-fructose-diet-induced obese mice model was treated with hydroxytyrosol for 14 weeks. The results showed that hydroxytyrosol improved the learning and memory abilities and enhanced the expressions of brain-derived neurotrophic factors (BDNFs) and postsynaptic density proteins, protecting neuronal and synaptic functions in obese mice.
Transcriptomic results further confirmed that hydroxytyrosol improved cognitive impairment by regulating gene expression in neural system development and synaptic function-related pathways.
Moreover, hydroxytyrosol treatment alleviated neuroinflammation in the brain of obese mice. To sum up, our results indicated that hydroxytyrosol can alleviate obesity-induced cognitive dysfunction by enhancing BDNF expression and alleviating neuroinflammation in the brain, which also means that hydroxytyrosol may become a potentially useful nutritional supplement to alleviate obesity-induced cognitive decline.
~Fill this form to download the dossier~
Discover the keys of the triple protection that we put at your disposal in this document. Fill this form to activate the download in pdf format.