Use of olive polyphenols for positive long term effects on cognition

Long-term feeding of a blend containing highly purified secoiridoid polyphenols including hydroxytyrosol provided beneficial effects on spatial working memory and motor coordination which were probably mediated by the increased ATP brain levels. Therefore, POS might represent a suitable nutraceutical for age-related cognitive decline (“Effects of Long-Term Treatment with a Blend of Highly Purified Olive Secoiridoids on Cognition and Brain ATP Levels in Aged NMRI Mice”; Oxid Med Cell Longev; Martina Reutzel et al 2018).

Aging represents a major risk factor for developing neurodegenerative diseases such as Alzheimer’s disease (AD). The multifactorial pathology makes it difficult to develop feasible therapies. there is growing interest in dietary patterns, stimulation of the brain, and physical activity as potential modifiable risk factors.

Mitochondrial dysfunction acts as a final pathway in both brain aging and AD.

Hytolive had demonstrated a newurpotection activity in rats, so it has been proposed as new promising agents to combat aging-associated neurodegeneration.

In this study on mices, gene expression of Sirt1, CREB, Gap43, and GPx-1 were significantly reduced in the brain tissue of aged mice. Olive polyphenols-fed mices showed improved spatial working memory. Furthermore, olive polyphenols including hydroxytyrosol restored brain ATP levels in aged mice which were significantly increased. A diet rich in purified olive polyphenols has positive long-term effects on cognition and energy metabolism in the brain of aged mice.